Project Two

PIE (Prostatectomy, Incontinence and Erectile function)

Project Co-Leaders
Dr. Graham Colditz, Chief and Niess-Gain Professor of Surgery, Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine

Dr. Adam S. Kibel, Professor of Surgery, Harvard Medical School; Chief of Urology, Brigham and Women's Hospital; and Chief of Urology, Dana Farber Cancer Institute

Co-Investigator
Dr. Robert Grubb III, Assistant Professor of Urologic Surgery, Division of Urologic Surgery

Project Summary
This team is leveraging two existing cohort studies and will implement supplemental data collection to evaluate the role of physical activity and obesity in urinary and sexual function following surgical treatment for prostate cancer, thus addressing an important patient-driven outcome. Furthermore, this team addresses the TREC goal of expanding translational research to cancer survivors and evaluates potential differences in outcomes by race.

Project Aims

  1. To determine the independent associations of pre-surgical physical activity (PA) and BMI on post-prostatectomy urinary and sexual function.
  2. To explore the interaction of PA and BMI on urinary and sexual function.
  3. To examine effect of change in PA and BMI from pre-surgery to 12 months post-op on urinary and sexual function.